Health & Personal Care Stores
NAICS 446: Health and personal care stores. US retail pharmacies, drugstores, PBM dynamics, and pharmacy industry trends.
Industry at a Glance
Sector-wide aggregates across all businesses classified under NAICS 446 (2017 classification frame). For specific sub-industries within this sector, see the individual reports below.
In NAICS 2022 this is part of 456, “Health and Personal Care Retailers”, which is broader.
Industry Overview
Health and personal care stores (NAICS 446) covers retail pharmacies, drugstores, optical goods retailers, and specialty health and wellness stores selling prescription medications, over-the-counter drugs, vitamins, beauty products, and medical supplies directly to consumers. The subsector has undergone dramatic consolidation and structural transformation, with CVS Health, Walgreens Boots Alliance, and Rite Aid historically dominating the pharmacy chain landscape, though Rite Aid's 2023 bankruptcy filing reduced the competitive field.
Prescription dispensing drives the economic engine: pharmacy operations typically generate 70-80% of revenue for major chains, with front-store merchandise (beauty, personal care, OTC medications) providing supplementary margin. Pharmacy benefit manager (PBM) reimbursement rates are the critical profitability variable. CVS Health's ownership of Caremark (the largest PBM) creates vertical integration advantages, while independent pharmacies operating under cooperative banners like Good Neighbor Pharmacy and Health Mart face persistent reimbursement pressure from the three dominant PBMs (Caremark, Express Scripts/Cigna, and OptumRx/UnitedHealth).
The subsector is regulated at both federal and state levels. DEA registration and controlled substance scheduling govern opioid and other scheduled drug dispensing. State boards of pharmacy license individual pharmacists and pharmacy locations. HIPAA privacy requirements apply to all prescription data handling. The expansion of pharmacy scope-of-practice laws in states like California and Oregon now permits pharmacists to prescribe hormonal contraceptives and initiate certain treatments, expanding the clinical role beyond traditional dispensing.
Who Uses These Reports
Trusted by professionals who need verified federal data to make decisions
Investors & PE Firms
Size markets, validate deal theses, and benchmark targets with verified federal data before committing capital
Consultants & Advisors
Deliver data-backed recommendations to clients with sourced and cited industry metrics — Census, BLS, and FRED
Founders & Operators
Validate market entry, benchmark against industry averages, and present credible data to investors and boards
Corporate Strategy Teams
Support expansion planning, M&A due diligence, and executive reporting with NAICS-classified industry data
See what's inside a report
Market sizing, workforce analysis, competitive landscape, regulatory environment — all sourced from Census, BLS, FRED, and SEC EDGAR.
Industry Trends
CVS Health and Walgreens are each closing 900+ locations through 2026 as e-commerce, reduced front-store traffic, and PBM reimbursement pressure undermine the economic model of traditional drugstore density
Amazon Pharmacy and Mark Cuban's Cost Plus Drugs are disrupting prescription pricing transparency and mail-order fulfillment, pressuring brick-and-mortar pharmacy margins on generic medications
State pharmacy scope-of-practice expansion in California (SB 493), Oregon, and Colorado now allows pharmacists to prescribe hormonal contraceptives, naloxone, and certain travel medications, creating new clinical revenue streams
PBM reform legislation advancing in Congress and at FTC targets rebate pass-through requirements and spread pricing practices that independent pharmacists argue suppress reimbursement below dispensing costs
Specialty pharmacy for high-cost biologics and gene therapies is growing rapidly as a revenue segment, with CVS Specialty, Walgreens-owned AllianceRx, and independents competing for contracts with manufacturers and health plans
Available Reports
1 industry report available for purchase under Health & Personal Care Stores.
Health & Personal Care StoresNAICS 44611 report▾
Specialty Reports Available on Request
Frequently Asked Questions
What is NAICS 446? ▾
How do pharmacy benefit managers affect drugstore profitability? ▾
Why are CVS and Walgreens closing hundreds of stores? ▾
What role does specialty pharmacy play in this subsector? ▾
How is pharmacy scope of practice expanding? ▾
Related Guides
Get verified retail industry trends data from federal sources. Total US Retail Employment: 15.5M (BLS Current Employment Statistics, April 2026).
Get verified retail profit margins data from federal sources. Average Retail Net Profit Margin: 2–5% (Industry Benchmarks, 2024).
Get verified pharmacy industry trends data from federal sources. US Pharmacy & Drug Store Employment: 691K+ (Census CBP, 2023).
Get verified pharmacy profit margins data from federal sources. Typical Pharmacy Net Profit Margin: 2–4% (Industry Benchmarks, 2025).
Get verified car dealership industry trends data from federal sources. US New Car Dealer Employment: 1.1M+ (Census CBP, 2023).
Questions about how we source industry data? See our data sources FAQ.
Don't see your industry?
We can generate a report for any NAICS-classified industry in the US. Professional PDF delivered in 48 hours.